Healthy Aging During Mid-life
The goal of this project is to identify small molecules that enhance health and perhaps increase longevity when treatment is started in mid-life. These studies will initially be performed in middle-aged mice. Those small molecules showing promising results would be prime candidates for further testing in mice and larger mammals. The ultimate aim, of course, is to delay age-related diseases and improve health in middle-aged people.
The Kaeberlein lab has been testing rapamycin because it influences the action of mTOR, a protein that regulates cell growth and metabolism. Their results indicate that providing rapamycin to middle-aged mice, even over only a short period, can significantly improve a variety of health markers and extend lifespan. Also under study are several natural products that target both mTOR and the functioning of mitochondria, the cell’s power generators.
Funding would directly support additional personnel to breed, work with and care for the animals at UW Medicine and cover the costs of test compounds and assays.
Photo by Clare McLean.
Director for Philanthropy
UW Medicine Advancement
206.543.7421 | email