George M. Martin, M.D.
Emeritus Professor, Department of Pathology
Associate Director of the Genetic Approaches to Aging Training Grant
The major current focus of our laboratory is on evaluating the role of age-related random changes in gene expression in the genesis of a wide range of geriatric pathologies, including most cancers, and a number of dementias of late life, including Azheimer’s disease and Parkinson’s disease. We also continue to discover novel gene mutations that appear to accelerate rates of aging; that research is made possible by an International Registry that receives biological samples from around the world
Honors and awards
1978-79 – Josiah Macy Jr. Foundation Faculty Scholar, Oxford University, Experimental Embryology (H. Harris, R. Gardner)
1991 – Humboldt Distinguished Scientist Award, Dept. Human Genetics, Univ. Wurzburg, Germany (Prof. H. Hoehn)
2000 – Lifetime Achievement Award, World Alzheimer Congress
200 – Distinguished Scientist Award, American Aging Association
2011 – Dart/New York University Biotechnology Achievement Award
2011 – SENECA Medal for Research into Aging, Industrial Club of Düsseldorf, Germany
2011 – Inaugural Science Award of the Buck Institute for Research in Aging
Martin GM, Sprague CA, Epstein CJ. (1970). Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest, 23:86-92.
Martin GM, Sprague CA, Norwood TH, Pendergrass WR. (1974). Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am J Pathol, 74: 137-54.
Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, Potter H, Heston LL, Martin GM. (1992). Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science, 258: 668-671.
Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD. (1996). Positional cloning of the Werner's syndrome gene. Science, 272: 258-62.
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. (2005). Extension of murine life span by overexpression of catalase targeted to mitochondria. Science, 308:1909-11.