David Marcinek, PhD
Associate Professor, Department of Radiology
Adjunct Associate Professor, Department of Bioengineering
Adjunct Associate Professor, Department of Pathology,
Co-Director, Translational Center for Metabolic Imaging
One area of research focus in the Marcinek lab is the influence of mitochondrial redox and energetics on skeletal muscle aging. The second interest is the effect of xenobiotics on mitochondrial function and physiology.
Honors and awards
2007 – Honoree, Early Career Award Symposium, University of Washington
2006 – Ellison Medical Foundation New Scholar Award in Aging
Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE. (2005). Reduced mitochondrial coupling in vivo alters cellular energetics in ageing mouse skeletal muscle. J Physiol, 569 (2): 467-473.
Amara CE, Shankland EE, Jubrias SA, Marcinek DJ, Kushmerick MJ, Conley KE. (2007). Mild mitochondrial uncoupling impacts cellular aging in vivo. Procs Nat Acad Sci USA, 104 (3): 1057-1062.
Siegel, MP, Kruse SE, Knowels, G, Schmiedl, C, Beyer R, Xie, H, Van Remmen, H, Smith, SR, Marcinek DJ. (2011). Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress. PLoS One, 6 (11): e26963.
Siegel, MP, Wilbur, T. Mathis, M, Shankland, EG, Trieu, A, Harper, M-E, Marcinek, DJ. (2013). Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mech Ageing Dev, 133 (9-10): 153-167.
Siegel, MP, Kruse, SE, Percival, JM, Goh, J, White , CC, Hopkins, HC, Kavanagh, TJ, Szeto, HH, Rabinovitch, PS, Marcinek, DJ. (2013). Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell, 12 (5): 763-761.