Brian Kraemer, PhD
Research Associate Professor of Medicine, Division of Gerontology and Psychiatry, Division of Neuroscience
Research Biologist, Geriatrics Research Education and Clinical Center, VA Puget Sound Healthcare System
Co-director, VA PSHCS Genetics Core Facility
We work to investigate the basic molecular mechanisms underpinning aging associated neurodegenerative disease using molecular genetic approaches in C. elegans, human cultured cells, and mice.
Honors and awards
2008 – VA Superior Performance Award
2002 – Alzheimer’s Association New Investigator Research Award: A C. elegans Model for Tauopathy
Liachko NF, McMillan PJ, Guthrie CR, Bird TD, Leverenz JB, Kraemer BC. (2013), CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Ann Neurol, 74: 39-52.
McCormick AV, Wheeler JM, Guthrie CR, Liachko NF, Kraemer BC. (2013). Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol Psychiatry, 73 (5): 464-71.
Guthrie CR, Greenup L, Leverenz JB, Kraemer BC. (2011). MSUT2 is a determinant of susceptibility to tau neurotoxicity. Hum Mol Genet, 20 (10): 1989-99.
Liachko NF, Guthrie CR, Kraemer BC. (2010). Phosphorylation promotes neurotoxicity in a model of TDP-43 proteinopathy. J Neurosci, 30 (48): 16208-19.
Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD. (2003) Neurodegeneration and defective neurotransmission in a C. elegans model of Tauopathy. Proceedings of the National Academy of Sciences (USA), 100 (17): 9980-9985.